PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes
Abstract
Osteoarthritis (OA) is a degenerative joint disease affecting a large population of people. Although the elevated expression of PKR (double stranded RNA-dependent protein kinase) and MMP-13 (collagenase-3) have been indicated to play pivotal roles in the pathogenesis of OA, the exact mechanism underlying the regulation of MMP-13 by PKR following inflammatory stimulation was relatively unknown. The purpose of this study was to determine the...
Paper Details
Title
PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes
Published Date
Apr 1, 2018
Journal
Volume
14
Pages
72 - 81
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