Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression
Abstract
Brain-intrinsic degenerative cascades are a proposed factor driving inflammatory lesion formation in multiple sclerosis (MS) patients. We recently described a model combining noninflammatory cytodegeneration (via cuprizone) with the classic active experimental autoimmune encephalomyelitis (Cup/EAE model), which exhibits inflammatory forebrain lesions. Here, we describe the histopathological characteristics and progression of these Cup/EAE...
Paper Details
Title
Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression
Published Date
Aug 24, 2017
Journal
Volume
65
Issue
12
Pages
1900 - 1913
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History