Effect of Nitric Oxide on Human Corneal Epithelial Cell Viability and Corneal Wound Healing

Although the wound healing effects of nitric oxide (NO) are known, the mechanism by which NO modulates corneal wound healing remains unclear. In this study, we investigated the effect of exogenous NO donor (NaNO 2 ) on corneal wound healing. We found that NaNO 2 (0.1 μM to 100 μM) increased human corneal epithelial cell (HCEC) viability and migration. It also modulated the phosphorylation of mitogen-activated protein kinases (MAPKs) in a time-...