Neurokinin 3 receptor antagonism decreases gonadotropin and testosterone secretion in healthy men

Summary Objective Patients with mutations of neurokinin B ( NKB ) and its receptor show hypogonadotrophic hypogonadism, but there is little evidence for the importance of this pathway in reproductive function in normal men, or its functional hierarchy with kisspeptin. Design An open label study wherein men (n = 6) were administered the NK 3R antagonist MLE 4901 40 mg orally twice a day for 7 days. Kisspeptin‐10 (0.3 μg/kg iv bolus) was given...