4,5‐Di‐O‐Caffeoylquinic Acid from Ligularia fischeri Suppresses Inflammatory Responses Through TRPV1 Activation

Ligularia fischeri (Ledeb.) Turcz., a perennial plant native to northeastern Asia, has long been used as folk remedies for the alleviation of inflammatory symptoms. We investigated whether the extract of L. fischeri ( LF Ex) and caffeoylquinic acid (CQA) derivatives, the pharmacologically active ingredients identified from L. fischeri , regulate inflammation via a transient receptor potential vanilloid 1 (TRPV1)‐mediated pathway. Changes in...