Variability in quantitative analysis of atherosclerotic plaque inflammation using 18F-FDG PET/CT

Background 18F-FDG-PET(/CT) is increasingly used in studies aiming at quantifying atherosclerotic plaque inflammation. Considerable methodological variability exists. The effect of data acquisition and image analysis parameters on quantitative uptake measures, such as standardized uptake value (SUV) and target-to-background ratio (TBR) has not been investigated extensively. Objective The goal of this study was to explore the effect of several...