Histone phosphorylation by TRPM6’s cleaved kinase attenuates adjacent arginine methylation to regulate gene expression

Significance Ion channels are proteins that span the cell’s membrane and affect the rapid transfer of ions. Kinases are proteins that transfer a phosphate from ATP to specific substrates. In mammals, there are two unusual proteins, melastatin-related transient receptor potential (TRPM)6 and TRPM7, that have both functions. Here we show that TRPM6’s kinase and channel domains are functionally connected: The kinase is cleaved from the channel...