Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer's disease.

Published on Aug 2, 2017in Alzheimer's Research & Therapy6.116
· DOI :10.1186/S13195-017-0281-7
Emilie T. Reas13
Estimated H-index: 13
(UCSD: University of California, San Diego),
Donald J. Hagler88
Estimated H-index: 88
(UCSD: University of California, San Diego)
+ 11 AuthorsLinda K. McEvoy66
Estimated H-index: 66
(UCSD: University of California, San Diego)
Background Diffusion imaging has demonstrated sensitivity to structural brain changes in Alzheimer’s disease (AD). However, there remains a need for a more complete characterization of microstructural alterations occurring at the earliest disease stages, and how these changes relate to underlying neuropathology. This study evaluated the sensitivity of restriction spectrum imaging (RSI), an advanced diffusion magnetic resonance imaging (MRI) technique, to microstructural brain changes in mild cognitive impairment (MCI) and AD.
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