PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.

Volume: 45, Issue: 18, Pages: 10492 - 10503
Published: Oct 13, 2017
Abstract
Telomerase is highly expressed in cancer and embryonic stem cells (ESCs) and implicated in controlling genome integrity, cancer formation and stemness. Previous studies identified that Kruppel-like transcription factor 4 (KLF4) activates telomerase reverse transcriptase (TERT) expression and contributes to the maintenance of self-renewal in ESCs. However, little is known about how KLF4 regulates TERT expression. Here, we discover...
Paper Details
Title
PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.
Published Date
Oct 13, 2017
Volume
45
Issue
18
Pages
10492 - 10503
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