PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.
Abstract
Telomerase is highly expressed in cancer and embryonic stem cells (ESCs) and implicated in controlling genome integrity, cancer formation and stemness. Previous studies identified that Kruppel-like transcription factor 4 (KLF4) activates telomerase reverse transcriptase (TERT) expression and contributes to the maintenance of self-renewal in ESCs. However, little is known about how KLF4 regulates TERT expression. Here, we discover...
Paper Details
Title
PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells.
Published Date
Oct 13, 2017
Journal
Volume
45
Issue
18
Pages
10492 - 10503
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