Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport

Significance Viruses are adept at exploiting the host cytoskeleton to facilitate various aspects of their replication. Among host cytoskeletal regulators, diaphanous-related formins (DRFs) coordinate actin nucleation and microtubule (MT) stabilization in response to various environmental signals. Here, we uncover a function of DRFs and show that human immunodeficiency virus type 1 (HIV-1) exploits DRFs to coordinate the disassembly of the viral...