Cross-sex testosterone therapy in ovariectomized mice: addition of low-dose estrogen preserves bone architecture.

Volume: 313, Issue: 5
Published: Nov 1, 2017
Abstract
Cross-sex hormone therapy (XHT) is widely used by transgender people to alter secondary sex characteristics to match their desired gender presentation. Here, we investigate the long-term effects of XHT on bone health using a murine model. Female mice underwent ovariectomy at either 6 or 10 wk and began weekly testosterone or vehicle injections. Dual-energy X-ray absorptiometry (DXA) was performed (20 wk) to measure bone mineral density (BMD),...
Paper Details
Title
Cross-sex testosterone therapy in ovariectomized mice: addition of low-dose estrogen preserves bone architecture.
Published Date
Nov 1, 2017
Volume
313
Issue
5
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