Loss of ADAMTS3 activity causes Hennekam lymphangiectasia-lymphedema syndrome 3.
Abstract
Primary lymphedema is due to developmental and/or functional defects in the lymphatic system. It may affect any part of the body, with predominance for the lower extremities. Twenty-seven genes have already been linked to primary lymphedema, either isolated, or as part of a syndrome. The proteins that they encode are involved in VEGFR3 receptor signaling. They account for about one third of all primary lymphedema cases, underscoring the...
Paper Details
Title
Loss of ADAMTS3 activity causes Hennekam lymphangiectasia-lymphedema syndrome 3.
Published Date
Nov 1, 2017
Journal
Volume
26
Issue
21
Pages
4095 - 4104
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Notes
History