Original paper

Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers

Volume: 16, Issue: 5, Pages: 1195 - 1199
Published: Aug 1, 2017
Abstract
Summary Reduced neurogenesis in the aging mammalian hippocampus has been linked to cognitive deficits and increased risk of dementia. We utilized postmortem human hippocampal tissue from 26 subjects aged 18–88 years to investigate changes in expression of six genes representing different stages of neurogenesis across the healthy adult lifespan. Progressive and significant decreases in mRNA levels of the proliferation marker Ki67 ( MKI 67 ) and...
Paper Details
Title
Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
Published Date
Aug 1, 2017
Journal
Volume
16
Issue
5
Pages
1195 - 1199
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