Dramatic rebounds of MS during pregnancy following fingolimod withdrawal

In MS, discontinuation of some therapies may result in a transitory, possibly overwhelming, increase in disease activity.1–4 We report 2 cases of severe clinical rebound after fingolimod suspension occurring in 2 patients following pregnancy. Clinical rebound was defined as the occurrence of new severe neurologic symptoms together with a significant increase of new or enlarging T2-weighted or gadolinium-enhancing T1-weighted lesions exceeding...