Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1
Abstract
An abnormal increase in glucocorticoid levels is responsible for pathological disorders affecting different organs and systems, and the selective inhibition of appropriate steroidogenic enzymes represents a validated strategy to restore their physiological levels. In continuing our studies on CYP11B inhibitors, in this paper a small series of 6-substituted 3-imidazolylmethylxanthones was designed and synthesized, according to the data acquired...
Paper Details
Title
Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1
Published Date
Oct 1, 2017
Volume
139
Pages
60 - 67
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