Oligomerization of the tetramerization domain of p53 probed by two- and three-color single-molecule FRET

Volume: 114, Issue: 33
Published: Jul 31, 2017
Abstract
Significance Intrinsically disordered proteins often form pathological oligomers implicated in various diseases. In many cases, these oligomers cannot be separated and characterizations of their sizes and conformations are difficult. We develop a single-molecule fluorescence method that can probe individual oligomers without separation and determine the equilibrium constants and oligomerization kinetics. By combining two- and three-color...
Paper Details
Title
Oligomerization of the tetramerization domain of p53 probed by two- and three-color single-molecule FRET
Published Date
Jul 31, 2017
Volume
114
Issue
33
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