Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma
Abstract
Induction of nonapoptotic cell death could be an approach to eliminate apoptosis-resistant tumors. We investigated necroptosis-based therapies in mouse models of pancreatic ductal adenocarcinoma cancer (PDAC).We screened 273 commercially available kinase inhibitors for cytotoxicity against a human PDAC cell line (PANC1). We evaluated the ability of the aurora kinase inhibitor CCT137690 to stimulate necroptosis in PDAC cell lines (PANC1,...
Paper Details
Title
Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma
Published Date
Nov 1, 2017
Journal
Volume
153
Issue
5
Pages
1429 - 1443.e5
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