Abstract 2186: Peptide-cleavable maytansinoid (ADCs) induce high bystander killing leading to improved anti-tumor activityin vivo

Volume: 77, Pages: 2186 - 2186
Published: Jul 1, 2017
Abstract
Antibodies targeting surface antigens on cancer cells typically have progressively lower access to tumor cells that are further removed from blood vessels. Also, the antibody will not bind to cells in the tumor mass that do not express antigen, including stromal cells of the tumor, many of which reportedly aid in the survival or metastasis of cancer cells. null ADCs can bind to antigen positive cancer cells, after which they are internalized and...
Paper Details
Title
Abstract 2186: Peptide-cleavable maytansinoid (ADCs) induce high bystander killing leading to improved anti-tumor activityin vivo
Published Date
Jul 1, 2017
Volume
77
Pages
2186 - 2186
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