Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer

Volume: 77, Issue: 21, Pages: 5846 - 5859
Published: Nov 1, 2017
Abstract
The lysyl oxidase-like protein LOXL2 has been suggested to contribute to tumor progression and metastasis, but in vivo evidence has been lacking. Here we provide functional evidence that LOXL2 is a key driver of breast cancer metastasis in two conditional transgenic mouse models of PyMT-induced breast cancer. LOXL2 ablation in mammary tumor cells dramatically decreased lung metastasis, whereas LOXL2 overexpression promoted metastatic tumor...
Paper Details
Title
Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
Published Date
Nov 1, 2017
Volume
77
Issue
21
Pages
5846 - 5859
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