CEST Nuclear Overhauser Enhancement Imaging of Protein Misfolding in Mice at Different Stages of Prion Disease

Published on Apr 22, 2016
Eleni Demetriou5
Estimated H-index: 5
,
E Demetriou1
Estimated H-index: 1
+ 4 AuthorsXavier Golay60
Estimated H-index: 60
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#1Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
#2Katharina S. Milde (DKFZ: German Cancer Research Center)H-Index: 1
Last. Moritz Zaiss (DKFZ: German Cancer Research Center)H-Index: 28
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Chemical exchange saturation transfer (CEST) is an MRI technique that allows mapping of biomolecules (small metabolites, proteins) with nearly the sensitivity of conventional water proton MRI. In living organisms, several tissue-specific CEST effects have been observed and successfully applied to diagnostic imaging. In these studies, particularly the signals of proteins showed a distinct correlation with pathological changes. However, as CEST effects depend on various properties that determine a...
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