Prostaglandins and Their Receptors in Eosinophil Function and As Therapeutic Targets

Of the known prostanoid receptors, human eosinophils express the prostaglandin D2 (PGD2) receptors DP1 (also DP, D-type prostanoid) and DP2 (also CRTH2, chemoattractant receptor homologous molecule expressed on Th2 cells), the prostaglandin E2 receptors EP2 and EP4, and the prostacyclin (PGI2) receptor IP. Prostanoids can bind to either one or multiple receptors, characteristically have a short half-life in vivo and are quickly degraded into...