Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain

Significance Although the incidence of chronic pain is estimated at 20–25% worldwide, optimal drug treatment regimens with few side effects have yet to be developed. In this study, we demonstrated that clodronate is a potent and selective inhibitor of vesicular ATP release that attenuates neuropathic and inflammatory pain unrelated to bone abnormalities. Clodronate was more effective and associated with comparatively fewer side effects than...