Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse

Background and Purpose Cysteinyl leukotrienes (CysLTs) are pro‐inflammatory lipid mediators that exacerbate disease state in several asthma phenotypes including asthma induced by allergen, virus and exercise. However, the role of CysLTs in irritant‐induced airway disease is not well characterized. The purpose of the current study was to investigate the effect of montelukast, a CysLT 1 receptor antagonist, on parameters of irritant‐induced asthma...