TFH-derived dopamine accelerates productive synapses in germinal centres
Abstract
Protective high-affinity antibody responses depend on competitive selection of B cells carrying somatically mutated B-cell receptors by follicular helper T (TFH) cells in germinal centres. The rapid T-B-cell interactions that occur during this process are reminiscent of neural synaptic transmission pathways. Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogranin B, which are normally found in...
Paper Details
Title
TFH-derived dopamine accelerates productive synapses in germinal centres
Published Date
Jul 1, 2017
Journal
Volume
547
Issue
7663
Pages
318 - 323
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