Antibody-drug conjugates in cancer

Antibody drug conjugates (ADCs) are emerging as powerful anti-cancer treatments. They are designed to combine the tumor specificity, pharmacokinetics and biodistribution properties of antibodies with the potent cell-killing activity of small molecules. The approval of brentuximab vedotin (Adcetris) for the treatment of Hodgkin lymphoma and trastuzumab emtansine (Kadcyla) for the treatment of metastatic breast cancer has spurred clinical...