ATP and cough reflex hypersensitivity: a confusion of goals?

We thank our friends M.G. Belvisi and J.A. Smith for their interest in our article. We are in agreement that cough hypersensitivity syndrome (CHS) is a clinical diagnosis, currently without a firm pathophysiological explanation. The exquisite sensitivity of patients with CHS to a wide variety of irritants is attested in every clinic and is a cardinal feature of the clinical history of this condition. The stunning effectiveness of AF-219/MK-7264...