Mitotic progression following DNA damage enables pattern recognition within micronuclei

The authors report a link between mitosis, the formation of micronuclei and DNA-damage-induced cGAS-dependent inflammation. Ionizing radiation and genotoxic cancer therapy induce innate immunity mechanisms and lead to an increased production of inflammatory cytokines. The delayed nature of this response, which occurs a few days after treatment, is not well understood. Roger Greenberg and colleagues report a link between mitosis, the formation of...