mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression

Volume: 24, Issue: 11, Pages: 1886 - 1899
Published: Jul 7, 2017
Abstract
The mammalian target of rapamycin (mTOR)/regulatory-associated protein of mTOR (Raptor) pathway transmits and integrates different signals including growth factors, nutrients, and energy metabolism. Nearly all these signals have been found to play roles in skeletal biology. However, the contribution of mTOR/Raptor to osteoblast biology in vivo remains to be elucidated as the conclusions of recent studies are controversial. Here we report that...
Paper Details
Title
mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression
Published Date
Jul 7, 2017
Volume
24
Issue
11
Pages
1886 - 1899
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