Effect of myelin water exchange on DTI-derived parameters in diffusion MRI: Elucidation of TE dependence

Purpose Water exchange exists between different neuronal compartments of brain tissue but is often ignored in most diffusion models. The goal of the current study was to demonstrate the dependence of diffusion measurements on echo time (TE) in the human brain and to investigate the underlying effects of myelin water exchange. Methods Five healthy subjects were examined with single‐shot pulsed‐gradient spin‐echo echo‐planar imaging with fixed...