Endothelial activation in patients with superficial vein thrombosis (SVT) of the lower limbs.

Published on Jun 27, 2017in Thrombosis Research2.869
· DOI :10.1016/J.THROMRES.2017.06.033
Emanuela Falcinelli24
Estimated H-index: 24
Benilde Cosmi42
Estimated H-index: 42
+ 7 AuthorsPaolo Gresele69
Estimated H-index: 69
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13 Citations
#1Nicholas L. Smith (UW: University of Washington)H-Index: 73
#2Laura B. Harrington (UW: University of Washington)H-Index: 12
Last. Bruce M. PsatyH-Index: 193
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Background Meta-analyses of randomized controlled trials suggest that treatment with hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) lowers the risk of incident venous thrombosis (VT), particularly among those without prevalent clinical cardiovascular disease (CVD). Whether this is true for the prevention of recurrent VT is debated. We used an observational inception cohort to estimate the association of current statin use with the risk of recurrent VT. Methods and Results The st...
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#1Hiroyuki Suzuki (Yokohama City University Medical Center)H-Index: 9
#2Yasushi Matsuzawa (Yokohama City University Medical Center)H-Index: 29
Last. Kazuo Kimura (Yokohama City University Medical Center)H-Index: 1
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Background: Venous thromboembolism (VTE) is a common and sometimes lethal postoperative complication of arthroplasty. Endothelial dysfunction is important in the pathogenesis of thrombus formation. Reactive hyperemia-peripheral arterial tonometry (RH-PAT) can noninvasively evaluate endothelial function. This study investigated the predictive value of RH-PAT for deep vein thrombosis (DVT) after lower limb arthroplasty. Methods and Results: A prospective observational study of 126 osteoarthritic p...
24 CitationsSource
Summary. Background: Optimal doses and duration of low-molecular-weight heparin (LMWH) for the treatment of superficial vein thrombosis (SVT) are still uncertain. Objectives: To compare the efficacy and safety of different doses and durations of LMWH parnaparin for symptomatic lower limb SVT. Patients and methods: Outpatients with at least a 4-cm-long SVT of long or short saphenous veins or their collaterals were randomized to receive parnaparin either 8500 UI once daily ( o.d.) for 10 days foll...
36 CitationsSource
#1Paolo Prandoni (UNIPD: University of Padua)H-Index: 105
#2Edoardo Casiglia (UNIPD: University of Padua)H-Index: 63
Last. Hervé Decousus (French Institute of Health and Medical Research)H-Index: 39
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Although it has been clearly demonstrated that venous thromboembolism is associated with an increased risk of subsequent overt cancer and arterial cardiovascular events in comparison with control populations, whether this association also applies to patients with isolated (ie, without concomitant involvement of the deep vein system) superficial vein thrombosis (SVT) in the legs is unknown. In 737 consecutive patients with isolated SVT not involving the sapheno-femoral junction, we conducted a re...
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#1Kirsten van Langevelde (LUMC: Leiden University Medical Center)H-Index: 6
#2Willem M. Lijfering (LUMC: Leiden University Medical Center)H-Index: 30
Last. Suzanne C. Cannegieter (LUMC: Leiden University Medical Center)H-Index: 60
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Superficial vein thrombosis (SVT) is regarded a self-limiting disorder, although the authors of recent studies showed that ultrasonographically diagnosed SVT is a precursor for venous thrombosis. We aimed to determine whether the same holds true for clinically diagnosed SVT and to what extent it is associated with thrombophilia in a population-based case-control study (ie, Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis). We found that a history of clinical SV...
39 CitationsSource
#1Maria Litzendorf (OSU: Ohio State University)H-Index: 3
#2Bhagwan SatianiH-Index: 23
Treatment of superficial venous thrombosis (SVT) has recently shifted as increasing evidence suggests a higher than initially recognized rate of recurrence as well as concomitant deep venous thrombosis. Traditional therapies aimed at symptom control and disruption of the saphenofemoral junction are being called into question. The incidence of deep venous thrombosis has been reported to be 6%–40%, with symptomatic pulmonary embolism occurring in 2%–13% of patients. Asymptomatic pulmonary embolism...
24 CitationsSource
#1Paolo Gresele (University of Perugia)H-Index: 69
#2Stefania MomiH-Index: 29
Last. Rino MigliacciH-Index: 9
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The association between venous thromboembolism and arterial thrombosis has emerged as consistent clinical observation in the last few years. While several experimental, epidemiological and pharmacologic studies support this association, the initial pathophysiological mechanism linking these two clinical conditions remains to be established. This review discusses the pathophysiological bases and a number of experimental and clinical observations suggesting that the common link between venous thro...
60 CitationsSource
#1Henrik Toft S⊘rensen (BU: Boston University)H-Index: 1
#2Erzsébet Horváth-Puhó (Aarhus University Hospital)H-Index: 32
Last. Paolo Prandoni (UNIPD: University of Padua)H-Index: 105
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Summary Background In some studies, venous thromboembolism has been associated with atherosclerosis and with the risk of arterial cardiovascular events such as myocardial infarction and stroke. Other studies, however, do not show this association. To help clarify these discrepant findings, we aimed to investigate the risk of arterial cardiovascular events in patients who were diagnosed with venous thromboembolism. Methods We undertook a 20-year population-based cohort study using data from natio...
319 CitationsSource
#1Rino Migliacci (University of Perugia)H-Index: 9
#2Cecilia BecattiniH-Index: 50
Last. Paolo Gresele (University of Perugia)H-Index: 69
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Background and Objectives A high incidence of atherosclerotic lesions and cardiovascular events has been reported in patients with spontaneous venous thromboembolism. Endothelial dysfunction is an early marker of atherosclerosis and has predictive value for ischemic events. We have evaluated endothelial function in patients with a history of spontaneous venous thromboembolism. Design and Methods Patients with a history of symptomatic, objectively confirmed, spontaneous venous thromboembolism wer...
79 CitationsSource
#1F. VerlatoH-Index: 16
#2Pietro ZucchettaH-Index: 25
Last. Andreozzi GmH-Index: 15
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Abstract Purpose: The rate of objectively proven pulmonary embolism in patients with thrombophlebitis of the greater saphenous vein was studied. Methods: Consecutive ambulant patients with thrombophlebitis of the greater saphenous vein, involving the above-knee segment, underwent a complete venous echo color Doppler examination of the lower limbs, perfusion lung scanning, and chest radiography. A high probability of pulmonary embolism was defined as the presence of two or more large segmental de...
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#1Ivan BudnikH-Index: 1
#1Ivan Budnik (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
Last. Alexander Brill (University of Birmingham)H-Index: 37
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Deep vein thrombosis (DVT) is a major origin of morbidity and mortality. While DVT has long been considered as blood coagulation disorder, several recent lines of evidence demonstrate that immune cells and inflammatory processes are involved in DVT initiation. Here, we discuss these mechanisms, in particular, the role of immune cells in endothelial activation, and the immune cascades leading to expression of adhesion receptors on endothelial cells. We analyze the specific recruitment and functio...
59 CitationsSource