ASSOCIATION OF APOE WITH COGNITIVE CHANGE IN COMMUNITY-DWELLING ADULTS: THE RANCHO BERNARDO STUDY

The E4 allele of the Apolipoprotein E (ApoE) gene increases risk for sporadic Alzheimer’s disease, yet it is unclear whether E4 accelerates cognitive decline in normal aging. This study examined the association between ApoE genotype and trajectories of cognitive change in community-dwelling older adults from the Rancho Bernardo Study, and assessed whether E4 effects were modulated by sex, education and lifestyle. Between 1988–2016, 1393 adults...