In silico model to simulate the radiation response at various fractionation from histopathological images of prostate tumors

Objectives: Using in silico simulations from histopathological cancer prostate specimen, the objectives were to identify the total dose corresponding to various fractionations necessary to destroy the tumor cells (50% to 99.9%) and to assess the impact of the Gleason score on those doses.Materials and methods: Histopathological specimens were extracted from 7 patients with delineated tumor foci and assigned Gleason scores (GS, indicator of tumor...