The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients

Whole-genome sequencing (WGS) in asymptomatic adults might prevent disease but increase health care use without clinical value.To describe the effect on clinical care and outcomes of adding WGS to standardized family history assessment in primary care.Pilot randomized trial. (ClinicalTrials.gov: NCT01736566).Academic primary care practices.9 primary care physicians (PCPs) and 100 generally healthy patients recruited at ages 40 to 65...