Polygenic risk score analysis of pathologically confirmed Alzheimer disease.
Abstract
Previous estimates of the utility of polygenic risk score analysis for the prediction of
Alzheimer’s disease have given Area Under the Curve estimates of <80%. However,
these have been based on the genetic analysis of clinical case control series. Here we
apply the same analytic approaches to a pathological case control series and show a
predictive AUC of 84%. We suggest that this analysis has clinical utility and that there is
limited room...
Paper Details
Title
Polygenic risk score analysis of pathologically confirmed Alzheimer disease.
Published Date
Aug 1, 2017
Journal
Volume
82
Issue
2
Pages
311 - 314
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