Eleven-year management of prostate cancer patients on active surveillance: what have we learned?

Published on Jun 14, 2017in Tumori1.707
· DOI :10.5301/TJ.5000649
C. Marenghi6
Estimated H-index: 6
,
Maria Francesca Alvisi5
Estimated H-index: 5
+ 31 AuthorsRiccardo Valdagni51
Estimated H-index: 51
(University of Milan)
Sources
Abstract
PurposeTo evaluate the outcomes of active surveillance (AS) on patients with low-risk prostate cancer (PCa) and to identify predictors of disease reclassification.MethodsIn 2005, we defined an inst...
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Active surveillance (AS) has evolved as a strategy alternative to radical treatments for very low risk and low-risk prostate cancer (PCa). However, current criteria for selecting AS patients are still suboptimal. Here, we performed an unprecedented analysis of the circulating miRNome to investigate whether specific miRNAs associated with disease reclassification can provide risk refinement to standard clinicopathological features for improving patient selection. The global miRNA expression profi...
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Abstract Context Evidence-based guidelines for active surveillance (AS), a treatment option for men with low-risk prostate cancer, recommend regular follow-up at periodic intervals to monitor disease progression. However, gaps in monitoring can lead to delayed detection of cancer progression, leading to a missed window of curability. Objective We aimed to identify the extent to which real-world observational studies reported adherence to monitoring protocols among prostate cancer patients on AS....
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