ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
Abstract
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be identified. During this time, our understanding of how these kinases regulate DNA repair and associated events has grown profoundly, although major questions remain unanswered. Here, we provide a historical perspective of their discovery and discuss their established...
Paper Details
Title
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
Published Date
Jun 1, 2017
Journal
Volume
66
Issue
6
Pages
801 - 817
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Notes
History