Original paper

Methylation of the ribosomal RNA gene promoter is associated with aging and age‐related decline

Volume: 16, Issue: 5, Pages: 966 - 975
Published: Jun 17, 2017
Abstract
The transcription of ribosomal RNA genes (rDNA) is subject to epigenetic regulation, as it is abrogated by the methylation of CpG dinucleotides within their promoter region. Here, we investigated, through Sequenom platform, the age-related methylation status of the CpG island falling into the rDNA promoter in 472 blood samples from 20- to 105-year-old humans and in different tissues (blood, heart, liver, kidney, and testis) of 15 rats 3-96 weeks...
Paper Details
Title
Methylation of the ribosomal RNA gene promoter is associated with aging and age‐related decline
Published Date
Jun 17, 2017
Journal
Volume
16
Issue
5
Pages
966 - 975
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