Synthesis and Antigenic Evaluation of Oligosaccharide Mimics of Vi Antigen fromSalmonella typhi

Salmonella typhi is responsible for typhoid fever, which is a serious health threat in developing countries. As a virulent factor of Salmonella typhi , the purified Vi polysaccharide (Vi PS) has become an effective vaccine to combat typhoid fever. The chemical synthesis can provide homogeneous and well‐defined molecules for the development of Vi‐based vaccines. However, the synthesis of Vi oligosaccharides in high yields and with exclusive...