Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
Abstract
The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes are extracellular vesicles generated by all cells, and are naturally present in the blood. Here we show that enhanced retention of exosomes, compared to liposomes, in the circulation of mice is likely due to CD47-mediated protection of exosomes from phagocytosis by monocytes and macrophages. Exosomes derived from normal...
Paper Details
Title
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
Published Date
Jun 1, 2017
Journal
Volume
546
Issue
7659
Pages
498 - 503
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