DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
Abstract
Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that the DNA exonuclease Trex1 is induced by radiation doses above 12–18 Gy in different cancer cells, and attenuates their immunogenicity by degrading DNA that accumulates in the cytosol upon radiation. Cytosolic DNA stimulates secretion of interferon-β by...
Paper Details
Title
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
Published Date
Jun 9, 2017
Journal
Volume
8
Issue
1
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