Original paper

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

eLife7.70
Volume: 6
Published: Jun 8, 2017
Abstract
Caspase-8 is a key player in extrinsic apoptosis and its activity is often downregulated in cancer. However, human Caspase-8 expression is retained in some tumors, including glioblastoma (GBM), suggesting that it may support cancer growth in these contexts. GBM, the most aggressive of the gliomas, is characterized by extensive angiogenesis and by an inflammatory microenvironment that support its development and resistance to therapies. We have...
Paper Details
Title
Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma
Published Date
Jun 8, 2017
Journal
Volume
6
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