Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation
Abstract
Malaria is a devastating parasitic disease affecting half of the world's population. The rapid emergence of resistance against new antimalarial drugs, including artemisinin-based therapies, has made the development of drugs with novel mechanisms of action extremely urgent. Proteases are enzymes proven to be well suited for target-based drug development due to our knowledge of their enzymatic mechanisms and active site structures. More...
Paper Details
Title
Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation
Published Date
Jul 3, 2017
Journal
Volume
284
Issue
16
Pages
2604 - 2628
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