Wound treatment by stem cells

Published on Jan 1, 2017
· DOI :10.1007/978-3-319-55687-1_10
Leyla Türker Şener4
Estimated H-index: 4
(Istanbul University),
Hakan Darici5
Estimated H-index: 5
+ 1 AuthorsErdal Karaoz26
Estimated H-index: 26
Various experimental or clinical studies in the literature have demonstrated the benefits of stem cells, especially mesenchymal stem cells. This chapter will focus on existing stem cell technologies and their applications in the treatment of wound healing. To understand mechanisms of stem cells in wound healing, we will go over the structure of most commonly wounded tissues, namely, skin, which consist of epithelia and connective tissue. Then we will explain wound healing process with three stages as inflammation, proliferation, and remodeling and the roles of tissue components during wound healing. Treatment of wounds is directly related with the cause, location, and degree of the wound. Therefore, we will describe common wound types with causes under two categories as acute and chronic. We will explain stem cell types which play an important role in tissue regeneration and wound healing in adult life owing to their high competency and self-renewal features. Here, we will give examples of various studies on various wound types with or without underlying diseases. Finally, we will describe recently developed methods such as the use of cells' own products, exosomes, and demonstrate the results of exosome therapies on chronic wounds with most recent examples on human trials.
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