Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Abstract
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed that colorectal cancers with mismatch repair deficiency were sensitive to immune checkpoint blockade with antibodies to programmed death receptor–1 (PD-1). We have now expanded this study to evaluate the efficacy of PD-1 blockade in patients with advanced mismatch repair–deficient cancers...
Paper Details
Title
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Published Date
Jul 28, 2017
Journal
Volume
357
Issue
6349
Pages
409 - 413
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