Liver X Receptor Activation Promotes Polyunsaturated Fatty Acid Synthesis in Macrophages

Volume: 35, Issue: 6, Pages: 1357 - 1365
Published: Jun 1, 2015
Abstract
Objective— Liver X receptors (LXRs) modulate cholesterol and fatty acid homeostasis as well as inflammation. This study aims to decipher the role of LXRs in the regulation of polyunsaturated fatty acid (PUFA) synthesis in macrophages in the context of atherosclerosis. Approach and Results— Transcriptomic analysis in human monocytes and macrophages was used to identify putative LXR target genes among enzymes involved in PUFA biosynthesis. In...
Paper Details
Title
Liver X Receptor Activation Promotes Polyunsaturated Fatty Acid Synthesis in Macrophages
Published Date
Jun 1, 2015
Volume
35
Issue
6
Pages
1357 - 1365
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