Rapid discovery and identification of the prototypes and their metabolites of Da-Huang-Xiao-Shi decoction in rat plasma by an integrative strategy based on liquid chromatography coupled with mass spectrometry

Da‐Huang‐Xiao‐Shi decoction has been used to treat damp‐heat jaundice for centuries in China. However, the absorbed components of the decoction and their related metabolites are little known until now. In this work, an integrative strategy based on liquid chromatography coupled with mass spectrometry (time‐of‐flight/triple‐quadruple tandem) was adopted to effectively identify the prototypes and their metabolites and to speculate the possible...