Molecular insights into the multilayered regulation of ADAM17: The role of the extracellular region
Volume: 1864, Issue: 11, Pages: 2088 - 2095
Published: Nov 1, 2017
Abstract
In contrast to many other signalling mechanisms shedding of membrane-anchored proteins is an irreversible process. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the major sheddases involved in a variety of physiological and pathophysiological processes including regeneration, differentiation, and cancer progression. Due to its central role in signalling the shedding activity of ADAM17 is tightly regulated, especially on the cell...
Paper Details
Title
Molecular insights into the multilayered regulation of ADAM17: The role of the extracellular region
Published Date
Nov 1, 2017
Volume
1864
Issue
11
Pages
2088 - 2095
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