24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma.

Published on Oct 1, 2017in Ophthalmology12.079
· DOI :10.1016/J.OPHTHA.2017.04.021
C Gustavo De Moraes9
Estimated H-index: 9
(CUMC: Columbia University Medical Center),
Donald C. Hood85
Estimated H-index: 85
(Columbia University)
+ 5 AuthorsJeffrey M. Liebmann74
Estimated H-index: 74
(CUMC: Columbia University Medical Center)
Sources
Abstract
Purpose To investigate the prevalence of visual field defects in glaucomatous eyes, glaucoma suspects, and ocular hypertensives with 24-2 and 10-2 visual fields. Design Prospective, cross-sectional study. Participants Patients with or suspected glaucoma tested with 24-2 and 10-2. Patients were classified into 3 groups on the basis of the presence of glaucomatous optic neuropathy (GON) and 24-2 visual field abnormalities: early glaucoma (GON and abnormal visual field, mean deviation >−6 decibels [dB]), glaucoma suspects (GON and normal visual field), and ocular hypertensives (normal disc, normal visual field, and intraocular pressure >22 mmHg). For the classification of visual field abnormalities, 24-2 and 10-2 tests performed on the same visit were analyzed. Main Outcome Measures Comparison of the prevalence of abnormal 24-2 versus 10-2 visual field results based on cluster criteria in each diagnostic group. Results A total of 775 eyes (497 patients) were evaluated. A total of 364 eyes had early glaucoma, 303 eyes were glaucoma suspects, and 108 eyes were ocular hypertensives. In the glaucoma group, 16 of the 26 eyes (61.5%) classified as normal based on cluster criteria on 24-2 tests were classified as abnormal on 10-2 visual fields. In eyes with suspected glaucoma, 79 of the 200 eyes (39.5%) classified as normal on the 24-2 test were classified as abnormal on 10-2 visual fields. In ocular hypertensive eyes, 28 of the 79 eyes (35.4%) classified as normal on the 24-2 were classified as abnormal on the 10-2. Patients of African descent were more likely to have an abnormal 10-2 result (67.3 vs. 56.8%, P  = 0.009). Conclusions Central visual field damage seen on the 10-2 test is often missed with the 24-2 strategy in all groups. This finding has implications for the diagnosis of glaucoma and classification of severity.
📖 Papers frequently viewed together
6 Authors (Ali S. Raza)
References27
Newest
#1Chunwei Zhang (HMU: Harbin Medical University)H-Index: 7
#2Andrew J. Tatham (UCSD: University of California, San Diego)H-Index: 25
Last. Linda M. Zangwill (UCSD: University of California, San Diego)H-Index: 96
view all 10 authors...
RESEARCH ARTICLE Macular Ganglion Cell Inner Plexiform Layer Thickness in Glaucomatous Eyes with Localized Retinal Nerve Fiber Layer Defects Chunwei Zhang 1,2 , Andrew J. Tatham 2,3 , Ricardo Y. Abe 2,4 , Na’ama Hammel 2 , Akram Belghith 2 , Robert N. Weinreb 2 , Felipe A. Medeiros 2 , Jeffrey M. Liebmann 5 , Christopher A. Girkin 6 , Linda M. Zangwill 2 * a11111 1 Department of Ophthalmology, the First Affiliated Hospital, Harbin Medical University, Harbin, China, 2 Hamilton Glaucoma Center, De...
Source
#1Michael Sullivan-Mee (Veterans Health Administration)H-Index: 13
#2My Tho Karin Tran (UNM: University of New Mexico)H-Index: 1
Last. Suchitra Katiyar (Murphy Oil)H-Index: 2
view all 5 authors...
Purpose To investigate the clinical characteristics of 10-2 visual field defects in subjects with a diagnosis of glaucoma or glaucoma suspicion. Design Prospective, observational cohort study. Methods From participants enrolled in an ongoing glaucoma research study at our institution, we identified 354 eyes in 180 subjects (97 with primary open-angle glaucoma, 83 with glaucoma suspicion) who had 2 or more reliable 24-2 and 10-2 visual field tests and good-quality spectral-domain optical coherenc...
Source
#1Saif Baig (UCSD: University of California, San Diego)H-Index: 4
#2Alberto Diniz-Filho (UCSD: University of California, San Diego)H-Index: 19
Last. Felipe A. Medeiros (UCSD: University of California, San Diego)H-Index: 84
view all 7 authors...
Importance Patients with glaucoma and a history of fast visual field loss might be at an increased risk for falls compared with those with a history of slow visual field loss, but, to date, this association has not been previously investigated in the literature. Objective To evaluate the association between self-reported falls and past rate of visual field loss in a cohort of patients with glaucoma followed up over time. Design, Setting, and Participants This observational cohort study included ...
Source
#1Lola M. Grillo (Columbia University)H-Index: 3
#2Diane Wang (Columbia University)H-Index: 7
Last. Donald C. Hood (Columbia University)H-Index: 85
view all 7 authors...
The macular region (i.e., ±8° from fixation) covers less than 2% of the retinal area, but contains over 30% of the retinal ganglion cells (RGCs).1 Glaucomatous damage to the macula (central ±8°) is relatively common, involves defects that are deep and local as well as those that are shallow and widespread, and can occur early in the disease process.2–11 Because central vision is necessary for tasks such as reading, recognizing faces, and driving,12 early detection of macular damage is vital to c...
Source
#1Hae-Young Lopilly Park (Catholic University of Korea)H-Index: 30
#2Bo-Een Hwang (Catholic University of Korea)H-Index: 1
Last. Chan Kee Park (Catholic University of Korea)H-Index: 28
view all 4 authors...
Purpose To investigate characteristics related to the presence of parafoveal scotoma on Humphrey 10-2 visual field (VF) in early glaucoma patients. Design Prospective, cross-sectional study. Methods participants: Ninety-one eyes from 91 patients with glaucomatous optic neuropathy were prospectively tested with a 10-2 VF test. observation procedures: Glaucoma patients were classified into eyes with or without parafoveal scotoma on 10-2 VF based on pattern deviation plot. The central 10 degree reg...
Source
To assess the extent to which glaucomatous damage of the macula can be detected using the summary statistics of a commercial report based upon the circumpapillary retinal nerve fiber layer (cpRNFL) thickness obtained with frequency domain optical coherence tomography (fdOCT).One hundred forty-three eyes of 143 open-angle glaucoma patients and suspects (56.4 ± 13.8 years) had 10-2 visual fields (VFs) and fdOCT macular and disc cube scans. RNFL and retinal ganglion cell plus inner plexiform layer ...
Source
#1Andrew J. Tatham (Edin.: University of Edinburgh)H-Index: 25
#2Felipe A. Medeiros (UCSD: University of California, San Diego)H-Index: 84
Last. Robert N. Weinreb (UCSD: University of California, San Diego)H-Index: 140
view all 4 authors...
Early diagnosis and treatment of glaucoma is important to reduce the risk of progressive and irreversible visual loss. The key to diagnosis is recognition of morphological changes to the optic nerve head and retinal nerve fiber layer, but in some patients, functional abnormalities are detected first. This review describes recent innovations with the potential to improve the early detection of glaucoma. Developments in imaging include novel optic nerve head metrics such as Bruch's membrane openin...
Source
Purpose We assessed the use of a customized, one-page structure + function report for aiding in detection of glaucomatous damage.
Source
Purpose To simulate modified versions of the 24-2 (6° grid) visual field (VF) test pattern by adding points from the 10-2 (2° grid) test pattern, and to assess their ability to detect early glaucomatous defects in the central 10°.
Source
#1Robert N. Weinreb (UCSD: University of California, San Diego)H-Index: 140
#2Tin Aung (NUS: National University of Singapore)H-Index: 109
Last. Felipe A. Medeiros (UCSD: University of California, San Diego)H-Index: 84
view all 3 authors...
Importance Glaucoma is a worldwide leading cause of irreversible vision loss. Because it may be asymptomatic until a relatively late stage, diagnosis is frequently delayed. A general understanding of the disease pathophysiology, diagnosis, and treatment may assist primary care physicians in referring high-risk patients for comprehensive ophthalmologic examination and in more actively participating in the care of patients affected by this condition. Objective To describe current evidence regardin...
Source
Cited By88
Newest
#1Aimee C. Chang (UCSD: University of California, San Diego)
#2Andrew Camp (UCSD: University of California, San Diego)H-Index: 8
Last. Robert N. Weinreb (UCSD: University of California, San Diego)H-Index: 140
view all 4 authors...
PURPOSE Visual field (VF) results that show more test points outside normal limits on the pattern deviation map than on the total deviation map have been assumed to be evidence of unreliable VF results. We propose the term pattern reversal to describe this VF finding and explore its association with paracentral loss. DESIGN Retrospective cohort and case-control studies. PARTICIPANTS Glaucoma and glaucoma suspect patients who completed VF testing in Veteran's Affairs ophthalmology or optometry cl...
Source
#1Ji Wook Hong (UOU: University of Ulsan)H-Index: 1
Last. Michael S. KookH-Index: 32
view all 6 authors...
PRECIS The 24-2C grid showed significantly greater structure-function (S-F) associations in the global and regional sectors than the 24-2 visual field (VF) grid in open-angle glaucoma eyes. PURPOSE The aim was to compare a Humphrey Field Analyzer (HFA) Swedish Interactive Threshold Algorithm-Faster (SITA-faster) 24-2C grid to a conventional HFA 24-2 grid regarding macular S-F relationships. METHODS The macular ganglion cell-inner plexiform layer thickness (mGCIPLT) was measured at different para...
Source
#1Huiyuan Hou (UCSD: University of California, San Diego)H-Index: 21
#2Sasan Moghimi (UCSD: University of California, San Diego)H-Index: 24
Last. Ryan Caezar Calaguas David (UCSD: University of California, San Diego)H-Index: 1
view all 11 authors...
Purpose null To characterize the change of ganglion cell complex (GCC) thickness and macular vessel density in glaucoma suspect eyes with ocular hypertension (OHT) or glaucomatous optic neuropathy (GON). null null null Design null Prospective, longitudinal study. null null null Participants null Eight-three eyes (24 healthy, 30 OHT, and 29 GON) of 65 patients who underwent at least 3 visits were included from the Diagnostic Innovations in Glaucoma Study. The mean follow-up was at least 3 years. ...
Source
#2Rafaella C. Penteado (UCSD: University of California, San Diego)H-Index: 15
#3Christopher Bowd (UCSD: University of California, San Diego)H-Index: 65
PURPOSE To evaluate the agreement between Compass New Grid (NG) and 10-2 test protocols for detecting early glaucomatous defects in the central 10 degrees of the visual field (CVFD). DESIGN Cross-sectional study. SUBJECTS AND CONTROLS A total of 123 eyes of 14 healthy individuals, 17 glaucoma suspects and 32 glaucoma patients were enrolled. METHODS Subjects performed NG and 10-2 Compass automated perimetry testing within one week. For both test protocols total deviation (TD) or pattern deviation...
Source
#1Kateki Vinod (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 8
#2Steven J. Gedde (UM: University of Miami)H-Index: 35
Last. Pradeep Y. Ramulu (Johns Hopkins University)H-Index: 32
view all 3 authors...
Abstract null null Objective null To identify 100 articles with significant impact on the clinical care of patients with glaucoma. null null null Design null Cross-sectional study. null null null Participants null 108 members of the American Glaucoma Society (AGS) in the original survey and 63 in the follow-up survey. null null null Methods null The 100 most frequently cited English-language original articles relevant to glaucoma were identified via a Scopus search. The American Academy of Ophth...
Source
#1Giovanni Montesano (UCL Institute of Ophthalmology)H-Index: 11
#2Allison M McKendrick (University of Melbourne)H-Index: 30
Last. Luca Rossetti (University of Milan)H-Index: 32
view all 12 authors...
Abstract null null Purpose null to evaluate the ability of additional central testing locations to improve detection of macular visual field (VF) defects in glaucoma. null null null Design null prospective cross-sectional study. null null null Participants null 440 healthy people and 499 patients with Glaucomatous Optic Neuropathy (GON) were tested with a fundus tracked perimeter (CMP, CenterVue, Italy) using a 24-2 grid with 12 additional macular locations (24-2+). null null null Methods null G...
Source
#1Ryan Caezar Calaguas David (UCSD: University of California, San Diego)H-Index: 1
#2Sasan Moghimi (UCSD: University of California, San Diego)H-Index: 24
Last. Christopher A. Girkin (UAB: University of Alabama at Birmingham)H-Index: 65
view all 12 authors...
PURPOSE To investigate the characteristics and rate of central visual field loss after optic disc hemorrhages (DH). DESIGN Prospective cohort study. METHODS 343 eyes of 220 subjects who had at least 3 years of follow-up with minimum of 5 visits with 10-2 and 24-2 visual field (VF) were recruited. Rates of 10-2 mean deviation (MD) loss in each hemifield and pre-defined zones were compared using linear mixed-effects model in DH and non-DH eyes. Clustered pointwise regression analysis was also used...
Source
#1Tutul Chakravarti (UCSD: University of California, San Diego)H-Index: 2
#2Mohamad MoghadamH-Index: 1
Last. Linda M. ZangwillH-Index: 96
view all 6 authors...
PRECI Moderate to substantial agreement between 10-2 and 24-2C perimetry for detecting central field defects suggests that adding central test points to the 24-2 protocol may improve efficiency of visual field testing for glaucoma management. PURPOSE To assess agreement between Humphrey Visual Field Analyzer 10-2 and 24-2C test protocols for detecting glaucomatous defects in the central 10° of the visual field (CVFDs). METHODS VFs from 165 eyes of 18 healthy individuals, 12 glaucoma suspects and...
Source
#1Michael Sullivan-Mee (Veterans Health Administration)H-Index: 13
Last. Denise PensylH-Index: 5
view all 7 authors...
PRECIS Using standard glaucoma structural and functional tests, clinicians accurately predicted presence/absence of 10-2 glaucomatous VF loss in 90% of the eyes in this study. PURPOSE To investigate how well clinicians with variable experience can predict presence and location of 10-2 visual field loss using structural and functional data that is routinely obtained for glaucoma assessment. METHODS Within a test set of 416 eyes (210 subjects) who were diagnosed glaucoma suspect or primary open-an...
Source
#1Yun Wen (SYSU: Sun Yat-sen University)
#2Zidong Chen (SYSU: Sun Yat-sen University)H-Index: 7
Last. Minbin Yu (SYSU: Sun Yat-sen University)H-Index: 20
view all 7 authors...
BACKGROUND/AIMS We aimed to explore the impact of glaucomatous macular damage, specifically retinal ganglion cell (RGC) loss, on macular pattern vision measured by the vanishing optotype (VO) recognition contrast threshold. METHODS Seventy-two patients (mean age, 33.51±7.05 years) with primary open-angle glaucoma and 36 healthy controls (mean age, 30.25±6.70 years) were enrolled. VO recognition contrast thresholds of each participant were measured at the 16 preset test locations covering the cen...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.