Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications
Abstract
Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a key role in reproduction and exerting functions in numerous nonreproductive tissues. In this review, we attempt to summarize the in vitro studies that are the basis of our current understanding of the mechanisms of action of ERα as a nuclear receptor and the key roles played by its two activation functions (AFs) in its transcriptional activities. We then...
Paper Details
Title
Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications
Published Date
Jul 1, 2017
Journal
Volume
97
Issue
3
Pages
1045 - 1087
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