Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis
Abstract
Esophageal adenocarcinoma (EAC) develops in an inflammatory microenvironment with reduced microbial diversity, but mechanisms for these influences remain poorly characterized. We hypothesized that mutations targeting the Toll-like receptor (TLR) pathway could disrupt innate immune signaling and promote a microenvironment that favors tumorigenesis. Through interrogating whole genome sequencing data from 171 EAC patients, we showed that...
Paper Details
Title
Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis
Published Date
May 22, 2017
Journal
Volume
13
Issue
5
Pages
e1006808 - e1006808
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